《蓝芩口服液配合干扰素α1b注射液对疱疹性咽峡炎患儿炎性因子及体液免疫水平的影响.docx》由会员分享,可在线阅读,更多相关《蓝芩口服液配合干扰素α1b注射液对疱疹性咽峡炎患儿炎性因子及体液免疫水平的影响.docx(8页珍藏版)》请在第一文库网上搜索。
1、蓝苓口服液配合干扰素1b注射液对疱疹性咽峡炎患儿炎性因子及体液免疫水平的影响陈玲,赵文静,孙艳西安市中心医院儿科,陕西西安710001【摘要】目的:探究蓝苓口服液配合干扰素1b注射液对疱疹性咽峡炎患儿炎性因子及体液免疫水平的影响。方法:选取2017年1月2023年1月于我院门诊收治的180例疱疹性咽峡炎患儿为受试对象,使用随机数字表法分为对照组和观察组,两组患者各90例。对照组患儿在常规治疗的基础上予以干扰素a1b注射液治疗,观察组患儿在对照组基础上联合蓝苓口服液进行治疗。比较两组患儿治疗后疗效、症状缓解时间差异,比较两组患者治疗前、治疗7d后中医证候积分、炎性因子C反应蛋白(CRP)、白细胞
2、介素/0(I1-IO).肿瘤细胞坏死因子-a(TNF-a)、体液免疫免疫球蛋白G(IgG)IgA、IgM水平差异。结果:治疗7d后,观察组患儿总有效率高于对照组(PVO.05);治疗后,观察组患儿症状缓解时间均低于对照组患儿(尸均V0.05);治疗7d后,两组患者CRP、I1-10、TNF-a、中医证候积分均较治疗前下降,且观察组低于同期对照组(P均V0.05);治疗7d后,两组患儿IgG、IgA、IgM均较治疗前上升,且观察组高于同期对照组(P均V0.05)。结论:蓝苓口服液配合干扰素a1b注射液对疱疹性咽峡炎患儿疗效显著,能促进患儿症状缓解,降低患儿中医证候积分、炎性因子水平,提高体液免疫
3、水平。【关键词】蓝苓口服液;干扰素a1b注射液;疱疹性咽峡炎;炎性因子;体液免疫Effectsof1anqinora11iquidcombinedwithinterferon1binjectiononinf1ammatoryfactorsandhumora1immunity1eve1inchi1drenpatientswithherpanginaChen1ing,ZhaoWenjingtSunYanDepartmentofPediatrics,Xi,anCentra1Hospita1,Xian710001,ChinaAbstractObjective:Toinvestigatetheeffec
4、tsof1anqinora11iquidcombinedwithinterferon1binjectiononinf1ammatoryfactorsandhumora1immunity1eve1inchi1drenpatientswithherpangina.Methods:180patientswithherpanginatreatedinoutpatientdepartmentofourhospita1fromJanuary2017toJanuary2023werese1ectedasthestudysubjects,andtheyweredividedintocontro1groupan
5、dobservationgroupbyusingrandomnumbertab1emethod,with90casesineachgroup.Thechi1drenpatientsincontro1groupweretreatedwithinterferon1binjectiononthebasisofconventiona1treatment,andthechi1drenpatientsinobservationgroupweretreatedwith1anqinora11iquidonthebasisofcontro1group.Theefficacyandre1ieftimesofsym
6、ptomsaftertreatmentwerecomparedbetweenthetwogroups,andtheTCMsyndromesscoresand1eve1sofinf1ammatoryfactorsC-reactiveprotein(CRP),inter1eukin-10(I1-10),tumornecrosisfactor-(TNF-a)andhumora1immunityimmunog1obu1inG(IgG),IgA,IgMbeforetreatmentandafter7doftreatmentwerecomparedbetweenthetwogroups.Resu1ts:A
7、fter7doftreatment,thetota1effectiverateinobservationgroupwashigherthanthatincontro1group(P0,05).Aftertreatment,there1ieftimesofsymptomsinobservationgroupwere1essthanthoseincontro1group(a11P0.05).After7doftreatment,the1eve1sofCRP,I1-10andTNF-andscoresofTCMsyndromesinthetwogroupswere1owerthanthosebefo
8、retreatment,andthe1eve1sandscoresinobservationgroupwere1owerthanthoseincontro1groupduringthesameperiod(a11P0.05).After7doftreatment,the1eve1sofIgG,IgAandIgMwereincreasedcomparedwiththosebeforetreatment,andthe1eve1sinobservationgroupwerehigherthanthoseincontro1groupatthesameperiod(a11PIgA、IgMJ水平。1.4
9、观察指标比较两组患儿治疗后疗效、症状缓解时间差异,比较两组患儿治疗前、治疗7d后中医证候积分、炎性因子(CRP、I1-10、TNFa)、体液免疫(IgG、IgA、IgM)水平差异。1.5 统计学方法本研究采用统计学软件SPSS22.0对数据进行分析处理,计数资料以百分率()表示,采用户检验对计数资料进行统计学检验,计量资料以均数土标准差(15)表示,采用/检验对计量资料进行统计学检验,PV0.05为差异有统计学意义。2结果2.1 疗效比较治疗7d后,观察组患儿总有效率高于对照组(PV0.05),见表2。表2治疗后两组患儿疗效比较n(%),n=90组别显效有效无效总有效率观察组46(51.11)42(46.67)2(2.22)88(97.78)对照组35(38.89)46(21.11)9(10.00)81(90.00)X2值6.1304.744P值0.0470.0292.2 症状缓解时间比较治疗后,观察组患儿症状缓解时间均低于对照组患儿(P均0.05),见表3。表3两组患儿症状缓解时