测量应用案例-32- 90Plus.docx

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1、测量应用案例-32-90P1us文献名：Cytotoxicityofa1uminumoxidenanopartic1esonA11iumceparoottip-effectsofoxidativestressgenerationandbiouptake作者：A.Rajeshwari1&S.Kavitha1&SruthiAnnA1ex1&DeepakKumar1&AnitaMukherjee2&NatarajanChandrasekaran1&AmitavaMukherjee11 CentreforNanobiotechnoIogy,V1TUniversity,Ve11ore,India2 Ce

2、ntreofAdvancedStudy,DepartmentofBotany,UniversityofCa1cutta,Ko1kata,India摘要：Thecommercia1usageofA12O3nanopartic1es(A12O3NPs)hasgoneupsignificant1yintherecenttimes,enhancingtheriskofenvironmenta1contaminationwiththeseagentsandtheirconsequentadverseeffectson1ivingsystems.Thecurrentstudyhasbeendesigned

3、toeva1uatethecytogeneticpotentia1ofA12O3NPsinA11iumcepa(roottipce11s)atarangeofexposureconcentrations(0.01,0.1,1,10,and100gm1),theiruptake/intema1izationprofi1e,andtheoxidativestressgenerated.Wenotedadose-dependentdecreaseinthemitoticindex(42to28%)andanincreaseinthenumberofchromosoma1aberrations.Var

4、iouschromosoma1aberrations,e.g.sticky,mu1tipo1arand1aggardchromosomes,chromosoma1breaks,andtheformationofbinuc1eatece11s,wereobservedbyoptica1,f1uorescence,andconfoca11aserscanningmicroscopy.FT-IRana1ysisdemonstratedthesurfacechemica1interactionbetweenthenanopartic1esandroottipce11s.ThebiouptakeofA12O3inparticu1ateform1edtoreactiveoxygenspeciesgeneration,whichinturnprobab1ycontributedtotheinductionofchromosoma1aberrations.关键词：A12O3NPs.A11iumcepa.Aberration.Biouptake.SOD