天津医科大学全英药理学实验教学大纲.docx

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1、THE OUTLINE OF PHARMACOLOGICAL EXPERIMENTSDepartment of Pharmacology, Tianjin Medical University2005.03PrefacePractical course of pharmacology is very important for students, because it affords students not only the basic pharmacological theories, but also the chances to learn about some basic techn

2、iques and methods of pharmacological research. This course includes both experiments carried out on isolated tissues or organs and experiments using whole animals. The experiments are of great importance for students.Experiment 1. Determination of Pharmacokinetic Parameters in One-Compartment ModelI

3、 Purpose:To comprehend the significance of the pharmacokinetic parameters in one-compartment model and to learn the determination and calculation of the parametersII Contents:A. Reviewing the concepts and significance of pharmacokinetic parametersB. Introduction of methods of determination and calcu

4、lation of pharmacokineticparameters in one-compartment modelC. Practice of some examples in classIII Time3.5 hours for teaching3.6 hour for practice0.5 hour for discussionExperiment 2. One-Compartment Open ModelI Purpose:To comprehend the significance of the pharmacokinetic parameters in one-compart

5、ment model and to practise the determination and calculation of the parametersII Contents:A. Introduction of the principle and method of the experimentB. Establishing the one-compartment model with the given instruments and the drugs including sodium salicylate, ferric chloride and chloroformC. Calc

6、ulation of the pharmacokinetic parameters in one-compartment model based on the determined dataD. DiscussionIII Time:0.5 hour for teaching2.0 hours for manipulation0.5 hour for calculation and discussionExperiment 3. Two-Compartment Open ModelI Purpose:To comprehend the significance of the pharmacok

7、inetic parameters in two-compartment model and to practise the determination and calculation of the parametersII Contents:A. Introduction of the principle and method of the experimentB. Establishing the two-compartment model with the given instruments and the drugs including salicylate acid-alcohol

8、solution, ferric chloride and chloroformC. Calculation of the pharmacokinetic parameters in two-compartment model based on the determined dataD. DiscussionIII Time:0.5 hour for teaching2.0 hours for manipulation0.5 hour for calculation and discussionExperiment 4. Determination of ED50 of Sodium Pent

9、obarbitalI Purpose:To comprehend the significance of ED50, to Ieam the method to determine ED50 and to calculate the ED50 of sodium pentobarbitalII Contents:A. Introduction of the principle and methods to determine ED50B. Manipulation with the Improved-Karber methodC. Calculation of the ED50 of sodi

10、um pentobarbitalD. DiscussionIH Time:0.5 hour for teaching2.0 hours for manipulation0.5 hour for calculation and discussionExperiment 5. Different Effects of Drugs by Different Routes of Administration and Different Dosage FormsI Purpose:To observe the effects of magnesium sulfate on mice by differe

11、nt routes of administration and the effects of strychnine on frogs by different dosage formsII Contents:A. Introduction of different routes of administration and different dosage forms of drugB. Administration of magnesium sulfate intraperitoneally and orally to different mice and administration of

12、strychnine in water solution and colloid solution to different frogsC. Observation and recording the resultsD. DiscussionIH Time:1.5 hours for teaching1.0 hour for manipulation and observation0.5 hour for discussionExperiment 6. Video and Discussion of the Drugs Affecting the Autonomic Nervous Syste

13、mI Purpose:To master the effects of cholinergic, anti-cholinergic, adrenergic and anti-adrenergic drugs on the blood pressure and heart rateII Contents:A. Teaching video about the drugs affecting the autonomic nervous systemB. Analysis and discussion of the effects of cholinergic, anti-cholinergic,

14、adrenergic and anti-adrenergic drugs on the blood pressure and heart rate according to the given figuresHI Time:1.0 hour for teaching video2.0 hours for analysis and discussionExperiment 7. Effects of Drugs Affecting the Sympathetic Nervous System on Blood Pressure in RabbitsI Purpose:To learn the m

15、ethod to record the acute blood pressure in the anesthetized animal and to observe the effects of adrenoceptor agonists and adrenoceptor antagonists on the blood pressure in rabbits II Contents:A. Introduction of the method to record blood pressure in the anesthetized rabbitsB. ManipulationC. Admini

16、stration and observationD. DiscussionIII Time:0.5 hour for teaching1.5 hours for manipulation0.5 hour for administration and observation0.5 hour for discussionExperiment 8. Intoxication and Detoxication of OrganophosphateI Purpose:To observe the symptoms of organophosphate poisoning and to obse,e the effects of atropine